Background: To determine the most accurate predictor in evaluating difficult visualization of larynx (DVL) using indicators of modified mallampati test (MMT), sternomental distance (SMD) and inter incisor gap (IIG), either in isolation or in combination. Methods: Two hundred eighty three patients were participated in the study and evaluated for their possibility of having DVL. The difficulty of larynx visualization was evaluated using direct laryngoscopy based on grading of the Cormack and Lehane (CL) classification. The CL grades III and IV were considered as difficult visualization of larynx. DVL was also predicted using the airway predictors of MMT, SMD and IIG. The cut-off points for the airway predictors were Mallampati III and IV; ≤ 12,5 cm, and ≤ 3 cm, respectively. Moreover, sensitivity, specificity, positive and negative predictive value and area under the curve (AUC) of each predictor were determined, either in isolation or in combination. Independent predictors of DVL were determined using logistic regression analysis. Results: Difficulty to visualize the larynx was found in 29 (10.2%) subjects. The sensitivity, specificity, positive predictive value and AUC for the airway predictors were: MMT (20.8%; 99.7%; 71.4%; 68%), SMD (72.4%; 97.2%; 75%; 88%), and IIG (41.4%; 99.4%; 85.7%; 73%). The best combination of predictors was SMD + IIG with an AUC of 90.2%. Triple combination of MMT + SMD + IIG showed the same value of AUC with combination of two predictors, SMD + IIG. Conclusion: This study suggests the combination of IIG + SMD predictors as the optimal diagnostic model to predict DVL in a Malay race population in Indonesia. Keywords: Difficult visualization of larynx (DVL), Mallampati score, Sternomental Distance (SMD), Inter incisor gap (IIG).
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